Link Between Tequin (gatifloxacin) and Hypoglycemia Strengthened -
IDSA: Link Between Tequin (gatifloxacin) and Hypoglycemia Strengthened - CME Teaching Brief - MedPage Today:
"This small and preliminary study supports a relationship between Tequin (gatifloxacin) and the development of hypoglycemia in older patients, especially if they have diabetes. Consider this association when selecting antibiotic therapy for elderly diabetic patients.
This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary as they have not yet been reviewed and published in a peer-reviewed publication.
Review
SAN FRANCISCO, Oct. 11 - Treatment with the fluoroquinolone Tequin (gatifloxacin) was strongly associated with hypoglycemia in elderly patients, particularly those with diabetes, according to a prospective cohort study.
Of 196 elderly patients enrolled in the study, 77 were taking Tequin and 119 a non-quinolone antibiotic. Ten patients developed hypoglycemia after Tequin dosing, whereas only one case occurred in the non-quinolone group, researchers reported at a meeting here of the Infectious Disease Society of America.
The rate of hypoglycemia differed significantly between the groups, with 13% in the Tequin treatment arm becoming hypoglycemic compared with 0.8% in the non-quinolone group (P=.0004, relative risk 15.4, 95% CI 2.02 - 118.33), said the researchers. "/.../
"This small and preliminary study supports a relationship between Tequin (gatifloxacin) and the development of hypoglycemia in older patients, especially if they have diabetes. Consider this association when selecting antibiotic therapy for elderly diabetic patients.
This study was published as an abstract and presented orally at a conference. These data and conclusions should be considered to be preliminary as they have not yet been reviewed and published in a peer-reviewed publication.
Review
SAN FRANCISCO, Oct. 11 - Treatment with the fluoroquinolone Tequin (gatifloxacin) was strongly associated with hypoglycemia in elderly patients, particularly those with diabetes, according to a prospective cohort study.
Of 196 elderly patients enrolled in the study, 77 were taking Tequin and 119 a non-quinolone antibiotic. Ten patients developed hypoglycemia after Tequin dosing, whereas only one case occurred in the non-quinolone group, researchers reported at a meeting here of the Infectious Disease Society of America.
The rate of hypoglycemia differed significantly between the groups, with 13% in the Tequin treatment arm becoming hypoglycemic compared with 0.8% in the non-quinolone group (P=.0004, relative risk 15.4, 95% CI 2.02 - 118.33), said the researchers. "/.../
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